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血浆中的胆碱酯酶：首次报道在班图人中缺失；半衰期测定。

Cholinesterase in plasma: first reported absence in the Bantu; half-life determination.

作者信息

Jenkins T, Balinsky D, Patient D W

出版信息

Science. 1967 Jun 30;156(3783):1748-50. doi: 10.1126/science.156.3783.1748.

DOI:10.1126/science.156.3783.1748
PMID:5611036
Abstract

A Bantu schoolgirl is the first non-Caucasoid found homozygous for the "silent" cholinesterase gene. Investigation of her family revealed two heterozygotes. The propositus possesses no antibody to normal cholinesterase. Transfused cholinesterase had in her a half-life of approximately 10 days.

摘要

一名班图族女学生是首个被发现的纯合子“沉默”胆碱酯酶基因的非白种人。对其家族的调查发现了两名杂合子。先证者体内不存在针对正常胆碱酯酶的抗体。输入她体内的胆碱酯酶半衰期约为10天。

相似文献

1
Cholinesterase in plasma: first reported absence in the Bantu; half-life determination.血浆中的胆碱酯酶：首次报道在班图人中缺失；半衰期测定。
Science. 1967 Jun 30;156(3783):1748-50. doi: 10.1126/science.156.3783.1748.
2
Initial experiences with the Cholinesterase Research Unit.
Br J Anaesth. 1970 Nov;42(11):1016-20. doi: 10.1093/bja/42.11.1016.
3
Identification of serum cholinesterase fluoride variants by differential inhibition in tris and phosphate buffers.
Clin Chem. 1972 Feb;18(2):105-9.
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Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods.对琥珀酰胆碱的延长反应：一种新型血浆胆碱酯酶变异体，传统表型分析方法将其鉴定为正常。
Anesth Analg. 1995 Aug;81(2):419-21. doi: 10.1097/00000539-199508000-00039.
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Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase.非典型血浆胆碱酯酶患者家庭中局部麻醉药毒性的调查。
J Oral Surg. 1975 Nov;33(11):833-7.
6
A family study of atypical plasma cholinesterase activity.
South Med J. 1970 Jul;63(7):772-6.
7
An original approach to the diagnosis of scoline-induced apnoea.琥珀胆碱诱发呼吸暂停的诊断新方法。
J Clin Pathol. 1972 May;25(5):422-6. doi: 10.1136/jcp.25.5.422.
8
[Familial examinations for the presence of atypical cholinesterase].[对非典型胆碱酯酶存在情况的家族性检查]
Ned Tijdschr Geneeskd. 1975 Oct 4;119(40):1544-7.
9
[Serum pseudocholinesterases. Preliminary study].
Anesth Analg (Paris). 1974 Sep-Oct;31(5):651-63.
10
[A rare case of silent cholinesterase genetic variant (author's transl)].[一例罕见的沉默型胆碱酯酶基因变异病例（作者译）]
Med Clin (Barc). 1980 Oct 25;75(7):309-11.

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The value of cholinesterase activity after Kasai operation.肝门空肠吻合术后胆碱酯酶活性的价值。
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6
Heterogeneity in the silent gene phenotype of psudocholinesterase of human serum.人血清假性胆碱酯酶沉默基因表型的异质性。
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Silent cholinesterase gene: variations in the properties of serum enzyme in apparent homozygotes.沉默胆碱酯酶基因：明显纯合子血清酶特性的变异
J Clin Invest. 1970 Mar;49(3):479-86. doi: 10.1172/JCI106257.