Popović Ljiljana, Batinica Stipe, Mestrović Tomislav, Zupancić Bozidar, Antabak Anko, Petrunić Mladen, Davila Slavko
Division of Anesthesiology and Reanimation, Department of Surgery, Clinical Hospital Center Zagreb, Kispatićeva 12, Zagreb, Croatia.
Pediatr Surg Int. 2003 Oct;19(8):605-7. doi: 10.1007/s00383-003-1054-x. Epub 2003 Sep 6.
Cholinesterase (ChE) is an enzyme synthesized in the liver. The aim of this study was to determine the value of ChE as an index of liver function. We measured the ChE activity as well as the values of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, aminotransferases and albumin before and 7 days after Kasai operation in 25 infants with biliary atresia. The increased activity of ChE in plasma after Kasai operation was accompanied by a decrease of other measured values ( P<0.0001), except for albumin. We can conclude that the increase of ChE activity together with the decrease of bilirubin, alkaline phosphatase and gamma-glutamyl transpeptidase show early improvement of liver function after Kasai operation. ChE activity can be used to assess liver function in terms of synthesis.
胆碱酯酶（ChE）是一种在肝脏中合成的酶。本研究的目的是确定ChE作为肝功能指标的价值。我们测量了25例胆道闭锁婴儿在Kasai手术后7天及术前的ChE活性以及胆红素、碱性磷酸酶、γ-谷氨酰转肽酶、转氨酶和白蛋白的值。Kasai手术后血浆中ChE活性增加，同时除白蛋白外的其他测量值下降（P<0.0001）。我们可以得出结论，ChE活性增加以及胆红素、碱性磷酸酶和γ-谷氨酰转肽酶下降表明Kasai手术后肝功能早期改善。ChE活性可用于从合成方面评估肝功能。
