金刚烷胺耐药性作为流感病毒的一种遗传标记。
Amantadine-resistance as a genetic marker for influenza viruses.
作者信息
Appleyard G
出版信息
J Gen Virol. 1977 Aug;36(2):249-55. doi: 10.1099/0022-1317-36-2-249.
PMID:561163
Abstract
The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
摘要
用对金刚烷胺耐药和敏感的流感病毒株混合物感染鸡胚、细胞培养物或小鼠，会导致毒株之间金刚烷胺耐药性或敏感性的转移。重组病毒对金刚烷胺的反应与其任何一种表面抗原均无关。对金刚烷胺的耐药性作为一种全或无的特性进行转移。结论是，金刚烷胺耐药性是流感病毒的一种有用的遗传标记。
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