基质蛋白基因决定流感病毒对金刚烷胺的敏感性。
The matrix protein gene determines amantadine-sensitivity of influenza viruses.
作者信息
Hay A J, Kennedy N C, Skehel J J, Appleyard G
出版信息
J Gen Virol. 1979 Jan;42(1):189-91. doi: 10.1099/0022-1317-42-1-189.
PMID:759556
Abstract
The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.
摘要
通过用对金刚烷胺敏感和耐药的流感病毒混合感染产生的几种重组毒株的基因组成，已与其对金刚烷胺的反应进行了比较。得出的结论是，对金刚烷胺耐药性或敏感性的转移由单个基因决定，该基因编码基质蛋白。
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