生物转化、性激素与两种挥发性麻醉剂对小鼠的毒性

Biotransformation, sex hormones, and toxicity of two volatile anesthetics in mice.

作者信息

Cascorbi H F, Gesinski R M, Komar M K

出版信息

J Toxicol Environ Health. 1976 May;1(5):839-42. doi: 10.1080/15287397609529383.

Abstract

Male and female DBA 11 mice recovered from 1 hr of anesthesia with chloroform of fluoroxene apparently unharmed. However, many of the animals died within 24-48 hr after anesthesia. Pretreatment with phenobarbital increased, while pretreatment with a small dose of carbon tetrachloride decreased, this toxicity. Relatively more males than females died. Pretreatment with estradiol in males and testosterone in females reversed this ratio. We conclude that the murine toxicity of chloroform and fluoxene is dependent on biotransformation by hepatic microsomal enzymes and that the testosterone enhances postanesthetic toxicity of these agents.

摘要

雄性和雌性DBA 11小鼠在经氯仿或氟烷麻醉1小时后恢复，显然未受伤害。然而，许多动物在麻醉后24至48小时内死亡。苯巴比妥预处理会增加这种毒性，而小剂量四氯化碳预处理则会降低这种毒性。死亡的雄性相对比雌性更多。雄性用雌二醇预处理和雌性用睾酮预处理可逆转这一比例。我们得出结论，氯仿和氟烷的小鼠毒性取决于肝微粒体酶的生物转化，并且睾酮会增强这些药物的麻醉后毒性。