Cascorbi H F, Gorsky B H, Redford J E
Br J Anaesth. 1976 May;48(5):399-402. doi: 10.1093/bja/48.5.399.
A sex difference in postanaesthetic mortality after fluroxene anaesthesia was found in Swiss Webster mice. More males succumbed than females. This toxicity was biotransformation-dependent and could be reversed by pretreatment with "opposite" sex hormones. The toxicity of the fluroxene metabolite trifluoroethanol also was more marked in male mice, but was only partially influenced by microsomal enzyme inhibitors or stimulators, or by sex hormones.
在瑞士韦伯斯特小鼠中发现了氟烷麻醉后麻醉后死亡率的性别差异。雄性死亡的比雌性多。这种毒性依赖于生物转化，并且可以通过用“相反”性激素预处理来逆转。氟烷代谢物三氟乙醇的毒性在雄性小鼠中也更明显，但仅部分受微粒体酶抑制剂或刺激剂或性激素的影响。
