Maghrabi R H, Waslien C I
Am J Clin Nutr. 1976 Feb;29(2):146-50. doi: 10.1093/ajcn/29.2.146.
Alterations in the carbohydrate composition of serum protein fractions have been determined in pooled sera from 35 children with protein-calorie malnutrition (PCM), 30 children treated for PCM, and 24 age- and social status-matched controls. Total protein-bound hexose (PBH), protein-bound sialic acid (PBSA), and protein-bound fucose (PBF) were elevated in PCM, but only PBF returned to control levels with treatment. Ratios of bound carbohydrate to protein in the unfractioned serum were elevated in PCM but PBH and PBF protein or globulin ratios returned to normal with treatment. The most marked change in carbohydrate composition occurred in the alpha1-globulin fraction. Molar ratios in the individual globulin fractions indicated an increase in carbohydrate moieties as follows: PBSA greater than PBH greater than PBF.
已对35名蛋白质 - 热量营养不良（PCM）儿童的混合血清、30名接受PCM治疗的儿童以及24名年龄和社会地位匹配的对照者的血清进行了血清蛋白组分碳水化合物组成变化的测定。PCM患者中总蛋白结合己糖（PBH）、蛋白结合唾液酸（PBSA）和蛋白结合岩藻糖（PBF）升高，但仅PBF在治疗后恢复到对照水平。未分级血清中结合碳水化合物与蛋白质的比值在PCM中升高，但PBH和PBF与蛋白质或球蛋白的比值在治疗后恢复正常。碳水化合物组成最显著的变化发生在α1球蛋白组分中。各个球蛋白组分中的摩尔比表明碳水化合物部分增加如下：PBSA＞PBH＞PBF。
