Edwards B R, Stern P
Pflugers Arch. 1977 Jul 19;369(3):281-3. doi: 10.1007/BF00582196.
Polyfructosan has been used as a substitute for inulin in GFR determinations. However, the validity of this substitution in conditions where renal tubular permeability to other substances, such as mannitol, sucrose and other substances, such as mannitol, sucrose and iothalamate, is increased has not been tested. Experiments were performed on 8 rats to compare the clearances of polyfructosan (CPF) and 14C-inulin (CIN) during hydropenia, 3% BW saline expansion, elevation of one ureteral catheter by 30 cm, and following return of increased ureteral pressure to the control level. No significant difference between CPF and CIN could be detected except in the kidney subjected to increased ureteral pressure. However, the magnitude of this difference--which may relate to the different molecular weights of the two compounds--was so small that we conclude that the use of CPF, as an index of GFR, is no less reliable than CIN under the conditions tested.
在肾小球滤过率（GFR）测定中，多聚果糖已被用作菊粉的替代物。然而，在肾小管对甘露醇、蔗糖和碘他拉酸盐等其他物质的通透性增加的情况下，这种替代的有效性尚未得到检验。对8只大鼠进行了实验，以比较禁水、3%体重盐水扩容、将一根输尿管导管抬高30厘米以及输尿管压力升高后恢复到对照水平期间多聚果糖清除率（CPF）和14C-菊粉清除率（CIN）。除了输尿管压力升高的肾脏外，CPF和CIN之间未检测到显著差异。然而，这种差异的幅度——可能与两种化合物不同的分子量有关——非常小，以至于我们得出结论，在测试条件下，使用CPF作为GFR的指标与CIN一样可靠。
