Gibbs M E, Ng K T
Pharmacol Biochem Behav. 1977 May;6(5):533-7. doi: 10.1016/0091-3057(77)90113-7.
Ouabain, administered 5 min prior to learning induces amnesia for a single-trial passive avoidance task in day-old chickens by inhibiting memory formation during the labile sodium-pump dependent phase. Amphetamine and norepinephrine (NE) successfully counteract ouabain-induced amnesia when administered immediately after learning. The actions of these drugs on ouabain-induced amnesia parallel that of diphenylhydantoin (DPH), and within similar time constraints. It is concluded that amphetamine (through release of NE) and norepinephrine exert their effects through stimulation of Na+/K+ ATP'ase activity. This conclusion is supported by the observation that these drugs do not overcome potassium chloride (KCl) inhibition of memory formation in the short-term phase prior to formation of labile sodium-pump dependent memory, and the fact that the noradrenergic blockers, propranolol and piperoxane do not alter the couteractive influence of DPH on cycloheximide (CXM) inhibition of the protein synthesis dependent long term memory phase which follows the labile phase.
哇巴因在学习前5分钟给药，通过抑制不稳定的钠泵依赖性阶段的记忆形成，诱导日龄雏鸡对单次被动回避任务产生失忆。苯丙胺和去甲肾上腺素（NE）在学习后立即给药时，能成功抵消哇巴因诱导的失忆。这些药物对哇巴因诱导失忆的作用与苯妥英（DPH）相似，且在相似的时间限制内。得出的结论是，苯丙胺（通过释放NE）和去甲肾上腺素通过刺激Na+/K+ ATP酶活性发挥作用。这一结论得到以下观察结果的支持：在不稳定的钠泵依赖性记忆形成之前的短期阶段，这些药物不能克服氯化钾（KCl）对记忆形成的抑制，以及去甲肾上腺素能阻滞剂普萘洛尔和哌克昔林不会改变DPH对环己酰亚胺（CXM）抑制不稳定阶段之后的蛋白质合成依赖性长期记忆阶段的对抗影响这一事实。
