Lozovskiĭ D V, Faktor M I, Gindilis V M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(5):695-701.
To elucidate the role of genetic factors in the increase of the blood serum LDH activity in schizophrenics', there have been studied 103 patients, 97 first degree nonpsychotic relatives, 58 healthy people and 32 pairs of likesex MZ and DZ twins (schizophrenics and normals). A correlation between the enzyme activity in the probands and their relatives is marked. With the aid of a quantitative estimation of the degree of genetic determination of the studied characteristic and special and twin methods the authors obtained the results fitting the hypothesis of additive polygenic inheritance with threshold manifestation.
为阐明遗传因素在精神分裂症患者血清乳酸脱氢酶（LDH）活性升高中的作用，对103例患者、97名一级非精神病亲属、58名健康人和32对同性同卵（MZ）及异卵（DZ）双胞胎（精神分裂症患者和正常人）进行了研究。先证者及其亲属的酶活性之间存在显著相关性。通过对所研究特征的遗传决定程度进行定量评估，并借助特殊方法和双胞胎方法，作者获得的结果符合具有阈值表现的加性多基因遗传假说。
