Baru A M, Sedykh L I, Kholodyĭ Iu G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(8):1201-7.
Experiments on male-rats with a chronic administration of lithium show that it exerts a dose-dependence ambivalent action on the biochemical and behavioural characterisics of "reseprine depressions". In this way changes in the catecholeamine excretion and disturbances of conditioned reactions of advoidance are prevented (in dosages 10 mg/kg , and increasing them to 50 mg/kg). An opposite influence of different doses of lithium was also seen in a study of the hypothalamic resources of noradrenalin in the remote period of an after action of reserpine. The use of lithium exerts an expressed preventive effect in experimental emotional stress, preventing the development of suprarenal reactions and disorders of conditioned reflexes of avoidance. The authors discuss some neurochemical mechanisms of ambivalent and emotiotropic effect of lithium and the exedience of an enlargement of its prophylactic use.
对雄性大鼠进行锂慢性给药实验表明，锂对“利血平抑郁症”的生化和行为特征具有剂量依赖性的矛盾作用。通过这种方式，可防止儿茶酚胺排泄的变化和回避条件反应的紊乱（剂量为10毫克/千克，并增加至50毫克/千克）。在对利血平作用后期的下丘脑去甲肾上腺素来源进行研究时，也观察到不同剂量锂的相反影响。锂的使用在实验性情绪应激中发挥明显的预防作用，可防止肾上腺反应的发生和回避条件反射的紊乱。作者讨论了锂的矛盾和情绪调节作用的一些神经化学机制以及扩大其预防用途的适宜性。
