Baru A M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1975;75(8):1211-7.
By a combination of biochemical and pharmacodynamical analyses the author conducted a differentiated study of the role of separate neurohormones (adrenalin, noradrenalin, dopamine, serotonine) and their interconnection with other regulating systems (corticosteroids, nucleic acids) in the neurochemical structure of experimental models in depressive behaviour (reserpine depressions, depressions due to inhibitors of dopamine-beta-oxydase). In the aspect of the author's concept concerning reciprocity of relationships between the central and peripheral catecholamine mechanisms on the basis of the obtained experimental data, their comparison with the previous clinico-biochemical investigations and literary data is considered to be the pathochemical basis of depression. This is considered to be a multicomponent structure of pathologically fixed changes of the central noradrenergic activity, relationships in the catecholaminergic system (hypothalamus--medullau substance of the adrenal glands) and processes of reswitching catecholamine influences on the state of other neurochemical regulatory systems.
通过生化和药效学分析相结合的方法，作者对单独的神经激素（肾上腺素、去甲肾上腺素、多巴胺、血清素）的作用及其与其他调节系统（皮质类固醇、核酸）在抑郁行为实验模型（利血平抑郁症、多巴胺-β-氧化酶抑制剂所致抑郁症）的神经化学结构中的相互联系进行了差异化研究。基于所获得的实验数据，从作者关于中枢和外周儿茶酚胺机制之间关系相互性的概念角度出发，将其与先前的临床生化研究及文献数据进行比较，被认为是抑郁症的病理化学基础。这被认为是中枢去甲肾上腺素能活动的病理固定变化、儿茶酚胺能系统（下丘脑 - 肾上腺髓质）中的关系以及儿茶酚胺对其他神经化学调节系统状态影响的重新转换过程的多组分结构。
