Fantl J A, Hurt W G, Dunn L J
Am J Obstet Gynecol. 1977 Oct 1;129(3):299-303. doi: 10.1016/0002-9378(77)90787-6.
Detrusor muscle dysfunction is a common reason for lower urinary tract symptomatology in women. This report summarizes observations in 35 patients diagnosed as having detrusor dysfunction. Similar involuntary detrusor contractions were observed in 25 incontinent patients and in five patients who were not incontinent but who had urgency and frequency of urination. The incontinent patients were separated into the "urge incontinence" group and the "detrusor dyssynergia" group, based on whether or not the detrusor contraction was preceded by a strong sensation of urge. The patients who were not incontinent were grouped as "urgency frequency syndrome." No patient had urinary tract infection, neurological, urologic, or metabolic disease. Thirty patients responded satisfactorily to similar management consisting of bladder drills and anticholinergic drug therapy. Decreased cortical inhibitory activity seems to be a common pathophysiologic mechanism.
逼尿肌功能障碍是女性下尿路症状的常见原因。本报告总结了35例被诊断为逼尿肌功能障碍患者的观察结果。在25例尿失禁患者以及5例虽未尿失禁但有尿急和尿频症状的患者中观察到了类似的逼尿肌不自主收缩。根据逼尿肌收缩前是否有强烈的尿意，将尿失禁患者分为“急迫性尿失禁”组和“逼尿肌协同失调”组。未尿失禁的患者归为“尿急尿频综合征”组。所有患者均无尿路感染、神经、泌尿或代谢疾病。30例患者对包括膀胱训练和抗胆碱能药物治疗在内的类似治疗反应良好。皮质抑制活动降低似乎是一种常见的病理生理机制。
