Demonstration of angiogenesis-activity in the corpus luteum of cattle.

The angiogenetic potency of corpus luteum tissue and of extracts of it was tested in three different biological model systems: the chorioallantoic membrane of the chicken (CMA), the ventral subcutaneous pouch of the mouse and the cheeck pouch of the Syrian hamster. The formation of new capillaries after transplantation of the materials was scored macroscopically and stereomicroscopically. In all three systems strong capillary reactions at the periphery of the transplants could be observed indicating the presence of a capillary inducing potency in the tissue of corpus luteum of the cattle.