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[单次及长期给予乙醇对动物多项代谢指标的影响]

[Effect of single and chronic administration of ethanol on several metabolic indices in animals].

作者信息

Nikulin A A

出版信息

Farmakol Toksikol. 1977 May-Jun;40(3):359-61.

PMID:561706
Abstract

The effect of one-time and 10-day long administration of ethanol (2 ml of a 20% solution per 100 g of body weight) on the activity of alcohol-, lactate-dehydrogenase, aspartate- and alanine-aminotransferase in cytostructures of different rats' organs was studied. One-time introduction of ethanol intensifies the processes of the amino acids transamination in individual cytostructures, reduces the activity of alcohol- and lactate-dehydrogenase. A course-wise administration of ethanol produces a still greater reduction of their activity.

摘要

研究了一次性和连续10天给予乙醇(每100克体重给予2毫升20%的溶液)对不同大鼠器官细胞结构中乙醇脱氢酶、乳酸脱氢酶、天冬氨酸转氨酶和丙氨酸转氨酶活性的影响。一次性给予乙醇会增强个别细胞结构中氨基酸的转氨作用,降低乙醇脱氢酶和乳酸脱氢酶的活性。连续给予乙醇会使其活性进一步降低。

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