Caprino L, Falchetti R, Borrelli F
Arzneimittelforschung. 1975;25(12):1920-3.
4,5-Diphenyl-2-bis(2-hydroxyethyl)aminoxazole (ditazole) 200 mg/kg administered orally for 3 days significantly reduced the one-stage prothrombin time in rats treated concomitantly with bishydroxycoumarin (BHC) or warfarin, orally or i.p., as compared with rats given only BHC or warfarin. No significant change occurred in heparin anticoagulant activity when it was administered to rats pretreated with ditazole for 3 days. Warfarin and BHC, in vitro or in vivo, did not influence platelet aggregation or the antiaggregating activity of ditazole. The co-administration of heparin and ditazole enhanced the antiaggregating activity of the two drugs in both in vivo and in vitro tests.
4,5-二苯基-2-双（2-羟乙基）氨基恶唑（双唑）以200毫克/千克的剂量口服给药3天，与仅给予双香豆素（BHC）或华法林的大鼠相比，在口服或腹腔注射给予双香豆素（BHC）或华法林的同时给药的大鼠中，显著缩短了一期凝血酶原时间。当对用双唑预处理3天的大鼠给药肝素时，肝素抗凝活性未发生显著变化。华法林和BHC在体内外均不影响血小板聚集或双唑的抗聚集活性。在体内和体外试验中，肝素与双唑联合给药均增强了这两种药物的抗聚集活性。
