De Gaetano G, Cavenaghi A E, Stella L
Haemostasis. 1977;6(3):190-6. doi: 10.1159/000214179.
Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) is a new drug shown to inhibit prostaglandin release from rat platelets. The present study indicates that ditazole, at doses similar to those inhibiting prostaglandin formation in rat, inhibits in vivo collagen--but not ADP-induced rat platelet aggregation. In addition, ditazole does not prolong the bleeding time in rats, but even tends to shorten it. This effect could be due to the inhibition of prostaglandin formation at the side of the vascular injury produced to induce bleeding.
地他唑（4,5-二苯基-2-双（2-羟乙基）氨基恶唑）是一种已被证明能抑制大鼠血小板释放前列腺素的新药。本研究表明，地他唑在与抑制大鼠前列腺素形成相似的剂量下，能在体内抑制胶原诱导的大鼠血小板聚集，但对ADP诱导的血小板聚集无抑制作用。此外，地他唑不会延长大鼠的出血时间，甚至有缩短出血时间的趋势。这种效应可能是由于抑制了诱导出血时血管损伤部位的前列腺素形成。
