Brady J, Liberatore F, Harper P, Greenwald P, Burnett W, Davies J N, Bishop M, Polan A, Vianna N
J Natl Cancer Inst. 1977 Nov;59(5):1383-5. doi: 10.1093/jnci/59.5.1383.
Diagnosed from 1970 through 1975, the annual incidence rate for angiosarcoma of the liver among residents of New York State (excluding New York City) was 0.25 per million. A case-control study indicated that direct exposure to arsenic, vinyl chloride (VC), and thorium dioxide was a significantly important factor in the etiology of this disorder (P less than 0.02). Direct exposure to these chemicals could not be demonstrated for 19 (73%) of the 26 study patients. The fact that 5 of these patients lived nearer to VC fabrication or polymerization plants than did their matched controls lent some support to the hypothesis that indirect modes of exposure, not specifically related to occupation, might be important in the etiology of this disorder.
在1970年至1975年期间被诊断出的纽约州（不包括纽约市）居民肝血管肉瘤的年发病率为百万分之0.25。一项病例对照研究表明，直接接触砷、氯乙烯（VC）和二氧化钍是该疾病病因中的一个显著重要因素（P小于0.02）。26名研究患者中有19名（73%）无法证明有直接接触这些化学物质的情况。其中5名患者比其匹配的对照更靠近VC制造或聚合工厂，这一事实为以下假设提供了一些支持：与职业无特定关联的间接接触方式可能在该疾病的病因中起重要作用。
