Rodeck C H, Campbell S, Biswas S
Br J Obstet Gynaecol. 1976 Jan;83(1):24-32. doi: 10.1111/j.1471-0528.1976.tb00725.x.
Plasma alpha-fetoprotein (AFP) has been estimated by radioimmunoassay in healthy non-pregnant adults, some of whom were taking oral contraceptives, and in women with normal and complicated pregnancies. A curve with the 90 per cent range in normal pregnancy was established. The prop&rtion of values below the 5th centile in complicated pregnancies was significantly greater than in uncomplicated pregnancies. However, three-quarters of the estimations in the complicated groups lay within the 90 per cent range. Nor correlation was found between maternal plasma AFP values and the incidence of fetal distress, small-for-dates babies or perinatal mortality. It is concluded that the measurement of maternal plasma AFP is not reliable test for predicting fetal well-being.
采用放射免疫分析法对健康未孕成年人（其中一些人正在服用口服避孕药）以及正常妊娠和妊娠合并症妇女的血浆甲胎蛋白（AFP）进行了测定。建立了正常妊娠90%范围的曲线。妊娠合并症患者中低于第5百分位数的值的比例显著高于未合并症妊娠者。然而，合并症组四分之三的测定值在90%范围内。未发现母体血浆AFP值与胎儿窘迫、小样儿或围产儿死亡率之间存在相关性。得出结论，测定母体血浆AFP不是预测胎儿健康的可靠试验。
