Grishchenko V I, Koliada L D, Demidenko D I
Probl Endokrinol (Mosk). 1977 Jul-Aug;23(4):68-70.
Melatonin content in the epiphysis, serotonin, noradrenaline, dopamine-in the hypothalamus, gonadotropins--in the hypophysis of rats was studied under normal conditions and following ovariectomy; regularly of the estral cycle phases was studied as well. Two series of experiments were conducted on 120 rats with regular estral cycles. The animals were divided into groups according to the estral cycle phase. Melatonin concentration in the epiphysis, serotonin, noradrenaline, dopamine--in the hypothalamus was subject to variations coinciding with the estral cycle phases. Serotonin, noradrenaline, and dopamine content decreased in the hypophysis of ovariectomized rats in comparison with control; melatonin content rose in the epiphysis. There was no complete extinction of the estral cycle in the course of investigation (20 days). The action of castration on the sexual cycle depended on the phase at which the rats were subjected to ovariectomy. A reverse relationship existed between the melatonin content in the epiphysis and serotonin content in the hypothalamus, this serving as one of the important factors in the regulation of the sexual function.
在正常条件下以及卵巢切除术后，研究了大鼠松果体中的褪黑素含量、下丘脑的血清素、去甲肾上腺素、多巴胺以及垂体中的促性腺激素；同时也研究了发情周期各阶段的规律性。对120只具有规律发情周期的大鼠进行了两组实验。根据发情周期阶段将动物分组。松果体中的褪黑素浓度、下丘脑的血清素、去甲肾上腺素、多巴胺会随着发情周期阶段发生相应变化。与对照组相比，卵巢切除大鼠垂体中的血清素、去甲肾上腺素和多巴胺含量降低；松果体中的褪黑素含量升高。在研究过程中（20天）发情周期并未完全消失。阉割对性周期的影响取决于大鼠接受卵巢切除时所处的阶段。松果体中的褪黑素含量与下丘脑的血清素含量呈反向关系，这是调节性功能的重要因素之一。
