赖氨酸加压素对大鼠戊四氮诱导的逆行性遗忘的影响。
Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.
作者信息
Bookin H B, Pfeifer W D
出版信息
Pharmacol Biochem Behav. 1977 Jul;7(1):51-4. doi: 10.1016/0091-3057(77)90009-0.
PMID:561964
Abstract
Lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial facilitated passive avoidance retention. Amnesia was produced when a single 50 mg/kg (IP) injection of pentylenetetrazol was given immediately following the passive avoidance acquisition trial. A single injection of lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial antagonized the amnesia.
摘要
在习得试验前1小时或24小时记忆保持试验前1小时给予赖氨酸加压素（1微克/大鼠，皮下注射），可促进被动回避记忆的保持。在被动回避习得试验后立即单次腹腔注射50毫克/千克的戊四氮会导致遗忘。在习得试验前1小时或24小时记忆保持试验前1小时给予单次赖氨酸加压素注射（1微克/大鼠，皮下注射）可对抗遗忘。
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