Fekete M, Van Ree J M, De Wied D
Peptides. 1986 Jul-Aug;7(4):563-8. doi: 10.1016/0196-9781(86)90027-6.
Disrupting circadian organization by exposing rats to a shifted illumination schedule after training for passive avoidance and shuttle box avoidance behavior resulted in retrograde amnesia as evidenced by impaired performance during retention and extinction testing respectively. A single treatment with either the ACTH-(4-9) analog ORG 2766 or desglycinamide9-(Arg8)-vasopressin (DGAVP) 1 hour prior to the retention of passive avoidance or extinction of shuttle box avoidance behavior restored the behavioral impairment. It is suggested that these peptides may be useful to relieve memory deficits induced by disturbances in circadian organization.
在对大鼠进行被动回避和穿梭箱回避行为训练后，通过使其暴露于改变的光照时间表来扰乱昼夜节律组织，结果分别在保持和消退测试期间表现受损，从而导致逆行性遗忘。在被动回避保持或穿梭箱回避行为消退前1小时，单次给予促肾上腺皮质激素-(4 - 9)类似物ORG 2766或去甘氨酰胺9-(精氨酸8)-加压素（DGAVP）可恢复行为损伤。提示这些肽可能有助于缓解由昼夜节律组织紊乱引起的记忆缺陷。
