糖皮质激素水平变化对家兔热暴露的影响。

Effects of changing levels of glucocorticosteroids on heat exposure in rabbit.

作者信息

Chowers I, Conforti N, Superstine E

出版信息

Jpn J Physiol. 1975;25(6):665-76. doi: 10.2170/jjphysiol.25.665.

DOI:10.2170/jjphysiol.25.665

Abstract

Rabbits exposed for one hour to a temperature of 40degrees Cand 35-37% humidity showed elevated plasma osmolality and pH. Most of the animals were not able to withstand the heat. Dexamethasone-treated rabbits under the same conditions withstood the heat better and their plasma pH and osmolality remained constant. Metopirone-treated rabbits withstood the heat and showed a rise in plasma osmolality and a slight change in plasma pH. The highest rise in rectal temperature was observed in the metopirone-treated rabbits. Only the untreated animals were unable to regain pre-exposure rectal temperature. The results suggest that high levels of glucocorticosteroids enhance neurogenic and metabolic mechanisms which have protective functions during acute exposure to heat.

摘要

暴露于40摄氏度、湿度为35 - 37%环境一小时的兔子，其血浆渗透压和pH值升高。大多数动物无法耐受高温。在相同条件下，接受地塞米松治疗的兔子对高温的耐受性更好，其血浆pH值和渗透压保持恒定。接受美替拉酮治疗的兔子能耐受高温，血浆渗透压升高，血浆pH值有轻微变化。美替拉酮治疗的兔子直肠温度升高幅度最大。只有未接受治疗的动物无法恢复到暴露前的直肠温度。结果表明，高水平的糖皮质激素可增强神经源性和代谢机制，这些机制在急性热暴露期间具有保护作用。