[Histoenzymologic characteristics of the human fetal pituitary under conditions of maternal hyperestrogenism].

The development of the fetus adenohypophysis analyzed under the conditions of high doses of sinestrol, administered to mothers, revealed certain morphofunctional characteristics in the group studied in comparison with the control. In normal pregnancy, a gradual increase in protein content and in nucleic acids activity are noted, as well as an increase in the enzymes in protein synthesis and transport within the cell. Under maternal hyperestrogenity, however, in the adenohypophyseal cells of 7--14 week-old fetuses, a decrease in the content of hormonal protein-precursors, nucleic acid activity, inhibition of synthesis and trnsport processes are observed.