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干扰素去除后发生的额外干扰分析

Analysis of additional interference occurring after the removal of interferon.

作者信息

Lockart R Z

出版信息

J Virol. 1967 Dec;1(6):1158-63. doi: 10.1128/JVI.1.6.1158-1163.1967.

DOI:10.1128/JVI.1.6.1158-1163.1967
PMID:5621487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375404/
Abstract

Cultures of chick cells exposed to interferon continued to decrease in virus-producing ability during incubation after the interferon was removed. The rate of development of the additional interference and the degree of viral interference finally manifested were dependent on the concentration of interferon to which the cultures were exposed and the time of exposure. Additional interference occurred also in infected cells. Additional interference was inhibited by actinomycin D and puromycin. The best explanation of additional interference is that it results from interferon that is fixed to the cells during their initial period of contact.

摘要

暴露于干扰素的鸡细胞培养物在去除干扰素后的孵育过程中，其产生病毒的能力持续下降。额外干扰的发展速度以及最终表现出的病毒干扰程度取决于培养物所暴露的干扰素浓度和暴露时间。额外干扰也发生在受感染的细胞中。放线菌素D和嘌呤霉素可抑制额外干扰。对额外干扰的最佳解释是，它是由细胞在最初接触期间固定的干扰素所致。

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本文引用的文献

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EFFECT OF ACTINOMYCIN D AND PUROMYCIN DIHYDROCHLORIDE ON ACTION OF INTERFERON.放线菌素D和盐酸嘌呤霉素对干扰素作用的影响。
Virology. 1964 Dec;24:586-8. doi: 10.1016/0042-6822(64)90211-9.
2
INHIBITION OF INTERFERON ACTION BY P-FLUOROPHENYLALANINE.
Nature. 1964 Jul 25;203:366-7. doi: 10.1038/203366a0.
3
PRODUCTION OF AN INTERFERON BY L CELLS INFECTED WITH WESTERN EQUINE ENCEPHALOMYELITIS VIRUS.感染西部马脑脊髓炎病毒的L细胞产生干扰素
J Bacteriol. 1963 Mar;85(3):556-66. doi: 10.1128/jb.85.3.556-566.1963.
4
Studies on an interferon from tickborne encephalitis virus-infected cells (IF). III. Antiviral action of IF.蜱传脑炎病毒感染细胞干扰素（IF）的研究。III. IF的抗病毒作用。
Acta Virol. 1962 Jan;6:9-16.
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Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.干扰素的生物学研究。I. 东部马脑脊髓炎病毒细胞感染的抑制
Virology. 1961 Mar;13:323-37. doi: 10.1016/0042-6822(61)90152-0.
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Persistence of active interferon in cells washed after treatment with interferon.
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Inhibition of interferon action by actinomycin.放线菌素对干扰素作用的抑制
Biochem Biophys Res Commun. 1964;14:447-51. doi: 10.1016/0006-291x(64)90084-1.

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