Morris D C, King S B, Douglas J S, Wickliffe C W, Jones E L
Circulation. 1977 Nov;56(5):841-4. doi: 10.1161/01.cir.56.5.841.
Twenty-three patients were evaluated by cardiac catheterization two to 12 months following aortic valve replacement with the porcine xenograft valve. These hemodynamic studies established a mean peak-to-peak systolic gradient across the prosthesis of 23 mm Hg with a range of 6-58 mm Hg. The mean effective orifice area was calculated to be 1.25 cm2. The effective orifice area increased with increasing valve size from 0.99 cm2 for the 19 mm prosthesis to 1.44 cm2 for the 25 mm prosthesis. While in general the hemodynamics of the porcine xenograft valve are comparable to other available prostheses, the exceedingly small orifice areas (0.99 cm2 and 1.03 cm2) calculated for the 19 mm and 21 mm prostheses render their use inadvisable.
23例患者在接受猪异种移植瓣膜主动脉瓣置换术后2至12个月接受了心导管检查评估。这些血流动力学研究显示，人工瓣膜两端的平均峰-峰收缩期压差为23 mmHg，范围为6-58 mmHg。平均有效瓣口面积经计算为1.25平方厘米。有效瓣口面积随瓣膜尺寸的增加而增大，从19毫米人工瓣膜的0.99平方厘米增至25毫米人工瓣膜的1.44平方厘米。虽然总体而言，猪异种移植瓣膜的血流动力学与其他现有人工瓣膜相当，但19毫米和21毫米人工瓣膜计算得出的瓣口面积极小（分别为0.99平方厘米和1.03平方厘米），因此不建议使用。
