Cohn L H, Sanders J H, Collins J J
Ann Thorac Surg. 1976 Sep;22(3):221-7. doi: 10.1016/s0003-4975(10)64906-5.
The Hancock porcine xenograft stabilized with the glutaraldehyde process was used for isolated aortic valve replacement in 71 patients from March, 1972, to July, 1975. Aortic stenosis was the primary diagnosis in 52 patients and aortic insufficiency in 19. There were 52 men and 19 women ranging in age from 18 to 82 years; 14 patients were older than 70 years. One patient was in Functional Class II, 50 in Class III, and 20 in Class IV preoperatively. Seventy-three patients undergoing Björk-Shiley aortic valve replacement during the same period are presented for comparison. The operative mortality was 3% (2 of the 71 patients); 4 of the remaining 69 patients (6%) died in the late postoperative period. No patient was placed on anticoagulation during the postoperative course, and there was 1 postoperative embolus in a patient with chronic atrial fibrillation (1.4%). With a mean follow-up period of 17 months, 60 patients are now in Functional Class I, 4 in Class II, and 1 in Class III. Seven patients have had transvalvular gradients and effective valve areas measured postoperatively that ranged from 32 to 5 mm Hg and 0.9 to 2.9 cm2 in 21 through 25 mm (OD) sizes.
1972年3月至1975年7月期间，71例患者接受了用戊二醛处理稳定化的汉考克猪异种移植物进行的主动脉瓣置换术。52例患者的主要诊断为主动脉瓣狭窄，19例为主动脉瓣关闭不全。患者中男性52例，女性19例，年龄在18至82岁之间；14例患者年龄超过70岁。术前，1例患者心功能为Ⅱ级，50例为Ⅲ级，20例为Ⅳ级。同期73例接受比约克-希利主动脉瓣置换术的患者作为对照。手术死亡率为3%（71例患者中有2例）；其余69例患者中有4例（6%）在术后晚期死亡。术后过程中没有患者接受抗凝治疗，1例慢性心房颤动患者发生了1次术后栓塞（1.4%）。平均随访17个月，目前60例患者心功能为Ⅰ级，4例为Ⅱ级，1例为Ⅲ级。7例患者术后进行了跨瓣压差和有效瓣口面积测量，21至25毫米（外径）尺寸的跨瓣压差范围为32至5毫米汞柱，有效瓣口面积范围为0.9至2.9平方厘米。
