Olley P M, Coceani F, Bodach E
Circulation. 1976 Apr;53(4):728-31. doi: 10.1161/01.cir.53.4.728.
Prostaglandin E2 (PGE2) has been used to maintain patency of the ductus arteriosus in four neonates with cyanotic congenital heart disease due to obstructive right heart malformations. PGE2 was infused prior to surgery, and in three patients, during surgery until a satisfactory aorto-pulmonary shunt was established. PGE2 produced consistently an immediate and persistent rise in arterial oxygen saturation, which could be ascribed to dilation of the ductus arteriosus. No major side effects occurred, except for pyrexia in two infants. All patients recovered well from surgery. We propose this treatment as preparation for surgery in any infant with congenital heart defects and ductus-dependent pulmonary blood flow. The same treatment may be useful preoperatively in patients with aortic interruption who also depend on continued patency of the ductus for blood supply to the lower half of the body.
前列腺素E2（PGE2）已被用于维持4例因右心梗阻性畸形导致的青紫型先天性心脏病新生儿的动脉导管通畅。PGE2在手术前输注，3例患者在手术期间持续输注，直至建立满意的主-肺动脉分流。PGE2持续使动脉血氧饱和度立即且持续升高，这可归因于动脉导管的扩张。除2例婴儿发热外，未出现重大副作用。所有患者术后恢复良好。我们建议将这种治疗作为任何患有先天性心脏缺陷和依赖动脉导管的肺血流的婴儿手术前的准备措施。同样的治疗方法术前对那些也依赖动脉导管持续通畅以向下半身供血的主动脉中断患者可能也有用。
