Lemanczyk S, Podolsak B
Klin Padiatr. 1977 Sep;189(5):313-20.
In 20 children with mumps and mumps meningitis thrombocyte functions, the thrombopoiesis and the platelet count were examinated over a four week period. The spontaneous, standardized platelet adhesion and aggregation on silikonized glass surface showed a statistically significant increase from the 5th to the 15th day of the illness. Within the first four days a decrease of the megathrombocyte portion respectively of the youngest platelet forms was noted as revealed by the platelet spreading preparations. Then the thrombopoiesis index as well as the platelet count arised from the 5th day of the illness parallel to the other platelet functions. The enhanced thrombopoiesis diminished at the end of the 3rd week of the illness but the platelet adhesion and aggregation continued to be further increased. A distinct correlation could be established between the development of the specific antibodies and increased platelet adhesion, aggregation and thrombopoiesis in epidemic parotitis. The influence of the immune complexes and of the virus itself, furthermore the occurrence of the regenerating phase as well as the effects of the possible thromboplastic activity following a tissue damage or an inflammatory reaction were discussed.
对20例患有腮腺炎及腮腺炎脑膜炎的患儿的血小板功能、血小板生成及血小板计数进行了为期四周的检查。在疾病的第5天至第15天，硅化玻璃表面的自发、标准化血小板黏附和聚集呈现出统计学上的显著增加。通过血小板铺展制剂发现，在发病的前四天，巨血小板部分以及最年轻血小板形式的比例有所下降。然后，从疾病的第5天起，血小板生成指数以及血小板计数与其他血小板功能同步上升。在疾病的第3周结束时，增强的血小板生成有所减弱，但血小板黏附和聚集继续进一步增加。在流行性腮腺炎中，特异性抗体的产生与血小板黏附、聚集及血小板生成增加之间可建立明显的相关性。此外，还讨论了免疫复合物和病毒本身的影响、再生期的出现以及组织损伤或炎症反应后可能的促凝血活性的作用。
