Pokrovsky A
Nutr Metab. 1977;21(1-3):194-6. doi: 10.1159/000175764.
Pathways of ethanol transformation and its respective metabolic disorders in the cell have been considered. One should note the role of acetaldehyde in the ethanol toxic effect. Acetaldehyde produces a significant effect upon the metabolism of biogenic amines in brain tissue. Chronic alcohol intoxication at a certain stage is connected with a considerable reduction in the ratio of alcohol dehydrogenase:acetaldehyde dehydrogenase (this ratio determines the severity of clinical signs in intoxication). The inhibition of acetaldehyde dehydrogenase activity is an enzymological base of hallucinations and delirium tremens. The importance of the protective role of nutrition at chronic alcohol intoxication is shown.
已经考虑了乙醇在细胞内的转化途径及其各自的代谢紊乱。应该注意乙醛在乙醇毒性作用中的作用。乙醛对脑组织中生物胺的代谢产生显著影响。在某个阶段，慢性酒精中毒与酒精脱氢酶：乙醛脱氢酶的比例显著降低有关（该比例决定了中毒临床症状的严重程度）。乙醛脱氢酶活性的抑制是幻觉和震颤谵妄的酶学基础。显示了营养在慢性酒精中毒中的保护作用的重要性。
