Majchrowicz E, Hunt W A, Lahti R A, Ogata M, Karoum F
Adv Exp Med Biol. 1977;85A:539-46. doi: 10.1007/978-1-4899-5181-6_33.
Ethanol has been shown to induce a shift in catecholamine metabolism peripherally from normally oxidative pathways to reductive pathways. The mechanisms of this effect may result from competitive inhibition of aldehyde dehydrogenase by acetaldehyde. The shift in metabolism cannot be found in brain and alterations in catecholamine function may reflect changes in the turnover of these amines.
乙醇已被证明会诱导儿茶酚胺代谢在外周从正常的氧化途径转变为还原途径。这种效应的机制可能是乙醛对醛脱氢酶的竞争性抑制所致。在大脑中未发现代谢的转变,儿茶酚胺功能的改变可能反映了这些胺类周转的变化。