Butcher R E, Vorhees C V, Kindt C W, Kazmaier-Novak K J, Berry H K
Pharmacol Biochem Behav. 1977 Aug;7(2):129-33. doi: 10.1016/0091-3057(77)90196-4.
Newborn rats injected on Days 1-8 of life with L-phenylalanine (2 g/kg) and p-chlorophenylalanine (80 mg/kg) displayed biochemical symptoms analogous to human phenylketonuria (PKU) and maze learning impairments. The behavioral effects were less evident in rats treated on Days 9-16 or 7-24. None of the symptoms observed were alleviated by simultaneous administration of melatonin (10 mg/kg/day).
在出生后第1至8天注射L-苯丙氨酸（2克/千克）和对氯苯丙氨酸（80毫克/千克）的新生大鼠表现出类似于人类苯丙酮尿症（PKU）的生化症状和迷宫学习障碍。在出生后第9至16天或第7至24天接受治疗的大鼠中，行为影响不太明显。同时给予褪黑素（10毫克/千克/天）并没有缓解所观察到的任何症状。
