Field T, McNelly A, Sadava D
Arch Int Pharmacodyn Ther. 1977 Aug;228(2):300-3.
Female rats were addicted to methadone via small dosages in their drinking water. The addicted animals were impregnated, and continued to receive the drug during pregnancy and lactation. Offspring were examined at birth and at age 21 days. Compared to controls whose mothers did not receive the drug, pups of addicted mothers at birth had significantly lower weight, brain weight and brain protein; litter size, brain DNA and brain acetylcholinesterase activity were not significantly different between the two groups. At age 21, pups of addicted mothers had significantly lower brain protein and brain acetylcholinesterase than did controls; body weight and brain DNA were not significantly different.
雌性大鼠通过在饮用水中添加小剂量美沙酮使其成瘾。让成瘾的动物受孕，并在怀孕和哺乳期继续给予该药物。对出生时和21日龄的后代进行检查。与母亲未接受药物的对照组相比，成瘾母亲的幼崽出生时体重、脑重和脑蛋白显著更低；两组之间的窝仔数、脑DNA和脑乙酰胆碱酯酶活性无显著差异。在21日龄时，成瘾母亲的幼崽脑蛋白和脑乙酰胆碱酯酶显著低于对照组；体重和脑DNA无显著差异。
