Thornhill J A, Hirst M, Gowdey C W
Can J Physiol Pharmacol. 1977 Oct;55(5):1170-8. doi: 10.1139/y77-160.
Male albino rats received injections of saline for 5 days before and 5 days after a series of 10 daily injections of dl-amphetamine, 1 or 5 mg/kg, sc. Core temperatures were measured every 30 min for 4 h after each injection and feeding activity (on a CRF operant schedule) every 30 min throughout. After amphetamine at either 0800 or 2000 h, a dose-related hyperthermia, stereotypic behavior, and an initial inhibition of feeding occurred. This anorexia decreased over the 4-h post injection period only in the evening-injected rats receiving 5 mg/kg. Mean body weights of all groups continued to increase during amphetamine administration. Mean 24-h food intake tended to remain below that in the control period and the hyperthermic response did not change significantly in any group. Initially on withdrawal from amphetamine all groups showed 'rebound' feeding. Taken with earlier reports, these results suggest that tolerance development to amphetamine-induced anorexia, hyperthermia, and stereotypic behavior occurs at different rates and is dependent upon frequency, route, dose, time, the amphetamine used, and whether the diet was restricted.
雄性白化大鼠在连续10天每天皮下注射1或5毫克/千克的dl-苯丙胺之前5天和之后5天接受生理盐水注射。每次注射后每30分钟测量核心体温4小时，并且在整个过程中每30分钟测量一次进食活动（按照条件性强化程序）。在08:00或20:00注射苯丙胺后，出现了剂量相关的体温过高、刻板行为以及最初的进食抑制。仅在晚上注射5毫克/千克的大鼠中，这种厌食在注射后4小时内有所减轻。在给予苯丙胺期间，所有组的平均体重持续增加。平均24小时食物摄入量倾向于保持低于对照期，并且任何组的体温过高反应均未显著变化。最初在停止使用苯丙胺时，所有组均出现“反弹性”进食。结合早期报告，这些结果表明，对苯丙胺诱导的厌食、体温过高和刻板行为的耐受性发展速率不同，并且取决于频率、途径、剂量、时间、所用苯丙胺以及饮食是否受限。
