Sever P S, Caldwell J, Williams R T
Psychol Med. 1976 Feb;6(1):35-42. doi: 10.1017/s0033291700007479.
It has been proposed that p-hydroxynorephedrine, a metabolite of amphetamine, is responsible for the tolerance that occurs to this drug. To test this idea, the development of tolerance to amphetamine has been examined in two species, the rat and the guinea pig, the former of which produces p-hydroxynorephedrine from amphetamine while the latter does not. In both species, tolerance develops to the anorectic and hyperthermic actions of amphetamine, and similar changes in the pattern of behavioural stimulation are seen.
有人提出，对羟基去甲麻黄碱（安非他明的一种代谢产物）是导致对该药物产生耐受性的原因。为了验证这一观点，研究人员在大鼠和豚鼠这两个物种中检测了对安非他明耐受性的发展情况，其中大鼠能将安非他明转化为对羟基去甲麻黄碱，而豚鼠则不能。在这两个物种中，对安非他明的厌食和体温升高作用都会产生耐受性，并且在行为刺激模式上也会出现类似的变化。
