Freed V H, Matin M A, Fang S C, Kar P P
Eur J Pharmacol. 1976 Jan;35(1):229-32. doi: 10.1016/0014-2999(76)90322-8.
Mipafox administered to rats daily for 35 days produced ataxia and a reduction in the level of dopamine in the corpus striatum. Treatment with Leptophos for the same period produced slight motor dysfunction and a small but significant reduction in the level of striatal dopamine. Fenitrothion neither produced motor dysfunction nor changed the level of striatal dopamine. The cholinesterase activity of corpus striatum was inhibited by all the compounds. The results suggest the possible involvement of striatal dopamine in the delayed neurotoxic effects of certain organophosphorus compounds.
每天给大鼠施用丙虫磷35天会导致共济失调，并使纹状体中的多巴胺水平降低。在同一时期用倍硫磷进行处理会产生轻微的运动功能障碍，且纹状体多巴胺水平有小幅但显著的降低。杀螟硫磷既未产生运动功能障碍，也未改变纹状体多巴胺水平。所有这些化合物均抑制了纹状体的胆碱酯酶活性。结果表明，纹状体多巴胺可能参与了某些有机磷化合物的迟发性神经毒性作用。
