Zharkovskiĭ A M
Farmakol Toksikol. 1977 Sep-Oct;40(5):517-21.
The effect of amantadine on various models of aggressiveness was investigated in experiments on male albino rats and mice. Amantadine (30-75 mg/kg) inhibited emotional reactivity and aggressiveness in models of shock- and apomorphine-induced aggression reproduced in rats. The drug also inhibited the isolation-induced aggressiveness in mice. In rats with bilaterally damaged caudate nucleus no inhibitory effect of amantadine on emotional behavior was in evidence, while in those with destroyed midbrain raphe nuclei this effect of amantadine was less ostensible by comparison with controls (sham-operated animals). It is suggested that the antiaggressive effect of amantadine is due to its stimulating action on the strial serotoninergic system.
在雄性白化大鼠和小鼠实验中，研究了金刚烷胺对各种攻击模型的影响。金刚烷胺（30 - 75毫克/千克）抑制了在大鼠中再现的休克和阿扑吗啡诱导攻击模型中的情绪反应性和攻击性。该药物还抑制了小鼠隔离诱导的攻击性。在双侧尾状核受损的大鼠中，未观察到金刚烷胺对情绪行为的抑制作用，而在中脑缝际核被破坏的大鼠中，与对照组（假手术动物）相比，金刚烷胺的这种作用不太明显。有人提出，金刚烷胺的抗攻击作用是由于其对纹状体5-羟色胺能系统的刺激作用。
