Brandt R B, Mueller D G, Schroeder J R, Guyer K E, Kirkpatrick B V, Hutcher N E, Ehrlich F E
J Pediatr. 1978 Jan;92(1):101-4. doi: 10.1016/s0022-3476(78)80086-9.
Serum vitamin A was determined in premature and term neonates by a specific spectrofluorometric method. Premature neonates (N = 42; gestational age = 32 +/- 0.4 weeks) had a serum vitamin A level (14.9 +/- 0.98 microgram/dl) significantly lower (P less than 0.001) than that of term neonates (N = 51; 22.4 +/- 0.99 microgram/dl). The vitamin A mean serum values of infants of 36 weeks' gestational age were not statistically different from those of the term neonates. Linear regression analysis for serum vitamin A values vs gestational age showed no significant correlation. A linear correlation (P less than 0.05), however, was found between serum vitamin A and serum protein protein concentrations, perhaps indicative of a lower concentration of retinol-binding protein. Since vitamin A is involved in the promotion of mucous-secreting cells, the premature neonate may be at greater risk than the term infant for diseases involving the mucosal epithelium, including necrotizing enterocolitis.
采用特定的荧光分光光度法测定早产儿和足月儿的血清维生素A水平。早产儿（N = 42；胎龄 = 32 ± 0.4周）的血清维生素A水平（14.9 ± 0.98微克/分升）显著低于足月儿（N = 51；22.4 ± 0.99微克/分升）（P < 0.001）。孕36周婴儿的维生素A平均血清值与足月儿相比无统计学差异。血清维生素A值与胎龄的线性回归分析显示无显著相关性。然而，血清维生素A与血清蛋白浓度之间存在线性相关性（P < 0.05），这可能表明视黄醇结合蛋白浓度较低。由于维生素A参与促进黏液分泌细胞的功能，早产儿患涉及黏膜上皮的疾病（包括坏死性小肠结肠炎）的风险可能比足月儿更高。
