Shenai J P, Chytil F, Stahlman M T
Pediatr Res. 1985 Sep;19(9):892-3. doi: 10.1203/00006450-198509000-00003.
This study assessed the liver vitamin A concentrations at birth in a group of very low birth weight neonates (n = 25) (less than 1500 g birth weight, less than 32 wk gestation), dying within 24 h of birth, prior to possible changes in vitamin A status induced by postnatal intervention. Serum concentrations of vitamin A and retinol-binding protein were also measured in 16 of these neonates. The mean (+/- SD) liver vitamin A concentration was 30.0 +/- 12.9 micrograms/g (range 2.0-49.0 micrograms/g). The mean (+/- SD) serum vitamin A concentration was 13.0 +/- 4.7 micrograms/dl (range 6.7-22.8 micrograms/dl). The mean (+/- SD) serum retinol-binding protein concentration was 2.2 +/- 0.8 mg/dl (range 1.5-4.8 mg/dl). Liver vitamin A, serum vitamin A, and serum retinol-binding protein concentrations did not correlate significantly with gestational age or birth weight. Linear regression analysis did not show a significant correlation between liver vitamin A, and serum vitamin A or retinol-binding protein concentrations. This study provides reference values for vitamin A concentrations at birth in very low birth weight neonates, which may be helpful in future studies designed to evaluate postnatal changes in the vitamin A status of these high-risk neonates.
本研究评估了一组极低出生体重新生儿（n = 25）（出生体重低于1500 g，胎龄小于32周）出生时的肝脏维生素A浓度，这些新生儿在出生后24小时内死亡，此时尚未受到产后干预引起的维生素A状态变化的影响。还对其中16例新生儿的血清维生素A和视黄醇结合蛋白浓度进行了测量。肝脏维生素A浓度的平均值（±标准差）为30.0±12.9微克/克（范围2.0 - 49.0微克/克）。血清维生素A浓度的平均值（±标准差）为13.0±4.7微克/分升（范围6.7 - 22.8微克/分升）。血清视黄醇结合蛋白浓度的平均值（±标准差）为2.2±0.8毫克/分升（范围1.5 - 4.8毫克/分升）。肝脏维生素A、血清维生素A和血清视黄醇结合蛋白浓度与胎龄或出生体重均无显著相关性。线性回归分析未显示肝脏维生素A与血清维生素A或视黄醇结合蛋白浓度之间存在显著相关性。本研究提供了极低出生体重新生儿出生时维生素A浓度的参考值，这可能有助于未来旨在评估这些高危新生儿出生后维生素A状态变化的研究。
