Coculescu M, Antipa C, Cucu C
Endocrinologie. 1977 Oct-Dec;15(4):275-81.
Five antidiuretic drugs were administered in each of twenty patients with cranial diabetes insipidus (DI). A daily intranasal dose of 10 microgram DDAVP (Adiuretin) produced longer and stronger antidiuretic effects than the posterior pituitary snuff, containing 100 microgram AVP, and than 12.5 microgram synthetic LVP spray, but a shorter antidiuresis than 12.5 microgram vasopressin tannate in oil, administered intramuscularly, antidiuresis lasting 14, 6, 4 and 36 hs respectively. Chlorpropamide produced an inconstant and less potent antidiuresis. 10microgram DDAVP given per nostril twice a day cancelled completely and without side effects DI in five patients with bronchospastic reaction to-pituitary snuff; the same daily dose was sufficient for the safe treatment of two DI women along pregnancy and lactation periods. It is recommended to use DDAVP as elective drug for the treatment of cranial DI.
对20例颅咽管型尿崩症患者分别给予5种抗利尿药物。每日经鼻给予10微克去氨加压素（弥凝）产生的抗利尿作用比含100微克抗利尿激素的垂体后叶鼻吸剂和12.5微克合成赖氨酸加压素喷雾剂更强且持续时间更长，但比肌肉注射12.5微克油剂鞣酸加压素产生的抗利尿作用持续时间短，抗利尿作用分别持续14、6、4和36小时。氯磺丙脲产生的抗利尿作用不稳定且效力较弱。对5例对垂体鼻吸剂有支气管痉挛反应的患者，每日每侧鼻孔给予10微克去氨加压素，可完全消除尿崩症且无副作用；相同的日剂量足以安全治疗两名处于妊娠和哺乳期的尿崩症女性。推荐使用去氨加压素作为治疗颅咽管型尿崩症的首选药物。
