去氨加压素（Adiuretin-SD，DDAVP）与鞣酸加压素在尿崩症中抗利尿作用的对比研究。
Comparative study of the antidiuretic effects of Adiuretin-SD (DDAVP) and Pitressin Tannate in diabetes insipidus.
作者信息
Czakó L, Julesz J, László F A
出版信息
Int J Clin Pharmacol Biopharm. 1978 Jan;16(1):10-3.
An account is given of experience acquired with the prolonged administration of a new vasopressin analogue, 1-deamino-8-D-arginine vasopressin (DDAVP), to patients with diabetes insipidus. The antidiuretic effect of this compound was compared with that of the long-acting Pitressin Tannate, containing a pituitary extract. It was found that DDAVP induces a far more significant antidiuretic effect than does Pitressin Tannate. Its application is not accompanied by any side effects, nor is its effectiveness decreassed after repeated administration. Similar conclusions were reached with the outpatient treatment of diabetes insipidus patients. The results indicate that nasally-administered Adiuretein-SD can be well utilized in the prolonged treatment of diabetes insipidus.
本文介绍了给尿崩症患者长期使用一种新型血管加压素类似物——1-去氨基-8-D-精氨酸血管加压素（DDAVP）所获得的经验。将该化合物的抗利尿作用与含有垂体提取物的长效鞣酸加压素的抗利尿作用进行了比较。结果发现，DDAVP诱导的抗利尿作用比鞣酸加压素更为显著。其应用不会伴随任何副作用，反复给药后其有效性也不会降低。对尿崩症患者进行门诊治疗也得出了类似结论。结果表明，经鼻给药的去氨加压素-SD可很好地用于尿崩症的长期治疗。
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