Levene C, Sela R, Rudolphson Y, Nathan I, Karplus M, Dvilansky A
Transfusion. 1977 Nov-Dec;17(6):568-72. doi: 10.1046/j.1537-2995.1977.17678075652.x.
A newborn infant of genotype P2p suffering from ABO-like hemolytic disease was born to a mother of the very rare genotype pp. The disease was severe enough to require exchange transfusions with pp blood. The mother and other members of the family with the same rare pp blood provided compatible donor blood for transfusions of the mother herself and for replacement transfusion of her affected infant. The mothers serum contained IgM molecules and also IgG molecules capable of crossing the placenta to induce a hemolytic process on the infant's red blood cells. The genotype of the P1 negative father was very likely P2P2 so that the genotype of the affected infant had to be P2p. A search of the literature revealed an earlier report from Japan in which the genotype of the P1 positive father was P1P2. As was to be expected the genotype of this affected infant was P2p.
一名基因型为P2p的新生儿患有类似ABO血型的溶血病，其母亲的基因型极为罕见，为pp。该病严重到需要用pp血型的血液进行换血治疗。母亲和家族中其他具有相同罕见pp血型的成员提供了相容的供血，用于母亲自身的输血以及对其患病婴儿的替代输血。母亲的血清中含有IgM分子以及能够穿过胎盘诱导婴儿红细胞溶血过程的IgG分子。P1阴性父亲的基因型很可能是P2P2，因此患病婴儿的基因型必定是P2p。查阅文献发现，日本曾有一份更早的报告，其中P1阳性父亲的基因型为P1P2。不出所料，这名患病婴儿的基因型也是P2p。
