Homan W P, Dineen P
Ann Surg. 1978 Jan;187(1):52-6. doi: 10.1097/00000658-197801000-00010.
Splenectomy in the treatment of thrombocytopenic purpura associated with lupus erythematosus has afforded satisfactory overall results in a group of ten patients. Postoperative deaths occurred in two patients, each of whom had significant underlying problems. Clinical manifestations of SLE-induced thrombocytopenic purpura included ecchymoses, petechiae, menorrhagia, epistaxis, and hematuria. Splenectomy in this disorder should be reserved for cases in whom corticosteroids do not produce satisfactory results, or in whom unacceptably high doses are required. Follow-up indicates long term control of thrombocytopenic purpura following splenectomy.
脾切除术治疗与红斑狼疮相关的血小板减少性紫癜，在一组10例患者中取得了令人满意的总体效果。两名患者术后死亡，他们各自都有严重的基础问题。系统性红斑狼疮所致血小板减少性紫癜的临床表现包括瘀斑、瘀点、月经过多、鼻出血和血尿。这种疾病的脾切除术应保留给那些使用皮质类固醇治疗效果不佳或需要使用高剂量皮质类固醇且剂量高得难以接受的病例。随访表明脾切除术后血小板减少性紫癜得到长期控制。
