Bertles J F, Borgese T A
J Clin Invest. 1968 Mar;47(3):679-89. doi: 10.1172/JCI105763.
Concurrent synthesis of two or more hemoglobins occurs in normal man, the human hemoglobinopathies, and certain animal species. Duck erythrocytes produced in response to acutely induced anemic hypoxia (hemolysis or blood loss) contained reciprocally altered proportions of Hb I (alpha(2) (I) beta(2) (I)) and Hb II (alpha(2) (II) beta(2) (II)); the relative proportion of Hb II was 50-100% increased. Relative rates of synthesis of the two hemoglobins remained proportional to their new concentrations throughout erythroid maturation. This information favors the proposal that relatively increased activity, not delayed decay, of biosynthetic processes responsible for net synthesis of Hb II had occurred. These studies support the concept that the individual biosyntheses of multiple hemoglobins, presumably under genetic control, are potentially manipulable, and they provide evidence for one mechanism leading in a reproducible fashion to alterations in net synthesis in vivo.
在正常人类、人类血红蛋白病以及某些动物物种中会同时合成两种或更多种血红蛋白。因急性诱导性贫血缺氧（溶血或失血）而产生的鸭红细胞中，血红蛋白I（α₂(I)β₂(I)）和血红蛋白II（α₂(II)β₂(II)）的比例呈相反变化；血红蛋白II的相对比例增加了50% - 100%。在整个红细胞成熟过程中，两种血红蛋白的相对合成速率与其新浓度保持成比例。这一信息支持了这样的观点，即负责血红蛋白II净合成的生物合成过程相对活性增加，而非延迟降解。这些研究支持了这样的概念，即多种血红蛋白的个体生物合成可能受基因控制，具有潜在的可操作性，并且它们为一种以可重复方式导致体内净合成改变的机制提供了证据。
