Wilson J D, Reinke R T
J Lipid Res. 1968 Jan;9(1):85-92.
The cholesterol-fed rat subjected to cannulation of the intestinal lymph duct and injected with acetate-2-(14)C has been utilized for a study of the mechanism by which cholesterol synthesized in the intestinal wall gains access to the circulation. It has been concluded that locally synthesized cholesterol is excreted bidirectionally, approximately half going into the lymph and half into the lumen. Furthermore, under the conditions of these experiments, little of the luminal cholesterol appears to be reabsorbed, which suggests that direct transfer from wall to lymph is the principal route for the entry of this endogenously derived cholesterol pool into the lymph and ultimately into the blood stream. Finally, it has been demonstrated that bile is required for this transfer of cholesterol from wall to lymph as well as for the absorption of dietary cholesterol.
用胆固醇喂养并进行肠淋巴管插管且注射了乙酸盐 - 2 -（14）C 的大鼠，已被用于研究肠壁合成的胆固醇进入循环系统的机制。得出的结论是，局部合成的胆固醇双向排泄，大约一半进入淋巴，一半进入肠腔。此外，在这些实验条件下，肠腔内的胆固醇似乎很少被重吸收，这表明从肠壁直接转移到淋巴是这种内源性胆固醇池进入淋巴并最终进入血流的主要途径。最后，已证明胆汁对于胆固醇从肠壁转移到淋巴以及膳食胆固醇的吸收都是必需的。
