Nakabou Y, Kashu T, Takano Y, Hagihira H
J Nutr Sci Vitaminol (Tokyo). 1978;24(2):205-12. doi: 10.3177/jnsv.24.205.
In studies on the cause of hypercholesterolemia in alloxan diabetic rats, the pool size and basal daily synthesis of conjugated bile salts were measured by the washout method and neutral sterols in the luminal contents were determined using cholestyramine. The results showed that in diabetic rats: 1) the biliary excretions of cholesterol and bile salts were significantly increased; 2) the pool size of conjugated bile salts was increased and its rate of synthesis was higher than in controls; 3) the amount of neutral sterols in the luminal contents doubled when cholesterol absorption was inhibited by administration of cholestyramine; 4) the amount of neutral sterols excreted in the feces was the same as in controls. Thus, it was concluded that hypercholesterolemia may be partly caused by an increased rate of intestinal absorption of cholesterol, derived mainly from sloughed off epithelial cells and bile, and due to facilitated micellar formation by the increased amount of bile salts in the intestine.
在关于四氧嘧啶糖尿病大鼠高胆固醇血症病因的研究中，采用洗脱法测定了结合胆汁盐的池大小和基础日合成量，并使用消胆胺测定了肠腔内容物中的中性固醇。结果显示，在糖尿病大鼠中：1）胆固醇和胆汁盐的胆汁排泄显著增加；2）结合胆汁盐的池大小增加，其合成速率高于对照组；3）当给予消胆胺抑制胆固醇吸收时，肠腔内容物中的中性固醇量增加一倍；4）粪便中排泄的中性固醇量与对照组相同。因此，得出结论，高胆固醇血症可能部分是由于肠道对胆固醇的吸收率增加所致，胆固醇主要来源于脱落的上皮细胞和胆汁，并且由于肠道中胆汁盐量增加促进了微胶粒的形成。
