Skehel J J, Hay A J, Armstrong J A
J Gen Virol. 1978 Jan;38(1):97-110. doi: 10.1099/0022-1317-38-1-97.
The results of analyses of fowl plague virus-specific RNA and protein synthesis in infected chick embryo fibroblasts incubated in amantadine hydrochloride are reported. They indicate that provided amantadine is present from the time of virus addition no expression of the virus genome occurs and that the synthesis of even the first detectable transcripts catalysed by the polymerase of the infecting virus particles is prevented. In agreement with previous reports it is concluded that amantadine prevents an unknown event which occurs immediately following virus infection.
本文报道了在感染鸡胚成纤维细胞中，于盐酸金刚烷胺存在的情况下对禽痘病毒特异性RNA和蛋白质合成的分析结果。结果表明，若从加入病毒时就存在金刚烷胺，则病毒基因组无表达，且感染病毒颗粒的聚合酶催化的首个可检测转录本的合成也被阻止。与先前报道一致，得出结论：金刚烷胺可阻止病毒感染后立即发生的一个未知事件。
