Thorbert G, Alm P, Rosengren E
Acta Obstet Gynecol Scand. 1978;57(1):45-8. doi: 10.3109/00016347809154198.
The uterine neurotransmitter, noradren,line, was examined histochemically and fluorometrically in guinea-pigs during the estrous cycle and after pretreatment with sex steroids. In diestrous animals noradrenaline values were higher than in the estrous state. Treatment with estradiol or progesterone alone did not markedly influence the level of uterine adrenergic transmitter, whereas combined estradiol and progesterone administration caused a clear-cut reduction in uterine noradrenaline. The quantitative changes in transmitter level did not reflect the marked alterations in weight during the various experimental conditions, and even inverse noradrenaline-weight relationships were observed. The findings offer further support for the concept of a steroid-mediated influence on uterine neurotransmission, where the uterine adrenergic nerves constitute a separate target for endocrine control, distinct from the rest of the uterus.
采用组织化学和荧光分析法，对处于发情周期以及经性甾体激素预处理后的豚鼠子宫神经递质去甲肾上腺素进行了检测。在动情间期动物中，去甲肾上腺素水平高于发情期。单独使用雌二醇或孕酮处理并未显著影响子宫肾上腺素能递质水平，而联合使用雌二醇和孕酮则导致子宫去甲肾上腺素明显减少。递质水平的定量变化并未反映出不同实验条件下子宫重量的显著改变，甚至观察到了去甲肾上腺素与重量之间的反向关系。这些发现进一步支持了甾体介导对子宫神经传递有影响这一概念，其中子宫肾上腺素能神经构成了内分泌控制的一个独立靶点，与子宫的其他部分不同。
