Pisciotta A V, Garthwaite T, Darin J, Aster R H
Am J Hematol. 1977;3:73-82. doi: 10.1002/ajh.2830030109.
Three successive patients with thrombotic thrombocytopenic purpura (TTP) were treated by exchange transfusion on a total of 5 occasions in addition to receiving more conventional therapy such as corticosteroids, platelet inhibitors, heparin, and splenectomy. Dramatic relief of symptoms and objective improvement in hematologic values occurred within 24 hours of each exchange. One patient subsequently died of complications resulting from a massive hemorrhage, but in hematologic remission. The remaining 2 are now apparently well. These observations appear to confirm recent reports of a beneficial effect of exchange transfusion in TTP. Although the reason for its effectiveness is not yet known, exchange transfusion may be a highly useful adjunct in the treatment of this disorder and further evaluation of this form of therapy appears warranted.
除接受皮质类固醇、血小板抑制剂、肝素和脾切除术等更传统的治疗外，连续3例血栓性血小板减少性紫癜（TTP）患者共接受了5次换血治疗。每次换血后24小时内症状显著缓解，血液学指标客观改善。1例患者随后死于大出血并发症，但处于血液学缓解状态。其余2例目前情况明显良好。这些观察结果似乎证实了近期关于换血治疗TTP有益效果的报道。尽管其有效性的原因尚不清楚，但换血治疗可能是治疗该疾病的一种非常有用的辅助方法，对这种治疗方式进行进一步评估似乎是有必要的。
