Sukernick R, Hanin A, Mosolov A
Clin Exp Immunol. 1968 Feb;3(2):171-7.
Blood lymphocytes from twenty-four patients with rheumatoid arthritis and twenty-two controls were incubated on monolayers of human fibroblasts in a serum-free medium. Lymphocytes from nineteen of the rheumatoid patients caused severe damage to the fibroblasts within 72 hr. The findings support the idea that sensitized lymphocytes play an important role in the pathogenesis of rheumatoid arthritis. The test may be useful in clinical practice in distinguishing rheumatoid from non-rheumatoid arthritis.
将24例类风湿性关节炎患者和22例对照者的血液淋巴细胞在无血清培养基中于人类成纤维细胞单层上进行培养。19例类风湿患者的淋巴细胞在72小时内对成纤维细胞造成了严重损伤。这些发现支持了致敏淋巴细胞在类风湿性关节炎发病机制中起重要作用的观点。该试验在临床实践中可能有助于区分类风湿性关节炎和非类风湿性关节炎。
